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what is myasthenia gravis



myasthenia gravis is neuromuscular disorder caused due to autoimmune production of antibodies against our nictotinic acetylcholine receptors. make makes acetylcholine fails to reach.

men at age 20 to 30
women age 50 to 70. females are common than males.

clinical features.
skeletal muscle weakness.
-improve with rest.-rest helps to increase acth
-days goes patient becomes weak-as day run acth will be reduced because as you use you loose.
-extraocular muscles are initally affected
ptosis
diplopia
blurred vision
-facial weakness
difficulty in speaking.-dysarthria.
difficulty in chewing .
sensory and deep tendon reflex is not affected.
myasthenic crisis-when respiratory muscles are affected patient cant breath. emergency condition.

diagnosis
acetylcholine receptor antibody test(specific)
emg
ct scan(rule out thymoma)
tensilon test.

treatment
ACHE inhibitors.
thymectomy.
immunosuppressive drugs.
plasmapheresis.
iv immunoglobulin therapy.

for visitors.
https://en.wikipedia.org/wiki/Myasthenia_gravis